Acute Diarrhea

Children in developing countries are continually exposed to enteric pathogens. This results in high rates of morbidity and mortality, especially in infants. Every day, over a thousand children die from diarrheal disease. With an estimated one billion cases affecting young children each year, diarrhea remains the second leading cause of death in children under the age of five after the neonatal period. Several factors such as antibiotic use, acute infection, and poor diet at an early age can greatly shift one’s bacterial composition, impacting development and correlating with an increased risk of developing a number of lifelong chronic diseases. The use of biotherapeutic agents or probiotics to treat a variety of infectious, most notably infections of mucosal surfaces are traditionally well known. With the encouraging results of feeding yogurt in lactose intolerant diarrheas, it was believed that probiotics may enhance lactose digestion and may produce antidiarrheal effect in different types of diarrhea.